histone deacetylase inhibitor

Background : Histone deacetylase inhibitor ( HDACi ) is a promising class of anticancer agents with high efficiency on inhibiting tumor growth , inducing cell differentiation and / or apoptosis .

研究背景：组蛋白去乙酰化酶抑制剂（HDACi）是一类能够有效抑制抑制肿瘤细胞增殖、诱导细胞分化、促进细胞凋亡的抗肿瘤新药。

Valproic Acid ( VPA ), a histone deacetylase inhibitor , could specifically inhibit the histone deacetylase activity , increase histone acetylation , and active gene expression in somatic cells .

丙戊酸（valproicacid，VPA）作为一种组蛋白去乙酰化酶抑制剂，能特异性抑制组蛋白去乙酰化酶的活性，提高细胞内组蛋白乙酰化水平，激活基因的表达。

Experimental study in vitro on histone deacetylase inhibitor MS-275 inhibiting bladder cancer

组蛋白去乙酰酶抑制剂MS-275抑制膀胱癌的实验研究

Effect of phenylbutyrate , a histone deacetylase inhibitor , on differentiation and apoptosis of Kasumi-1 cells

脱乙酰化酶抑制剂苯丁酸钠体外诱导Kasumi1细胞分化和凋亡作用

Enhancive Effect of Histone Deacetylase Inhibitor Trichostatin A on Transfection Efficiency of Adenovirus in Ovarian Carcinoma Cell Line A2780

HDAC抑制剂TSA增强卵巢癌细胞株A2780对腺病毒基因转染效率的体外研究

Intraperitoneal administration of sodium butyrate , a histone deacetylase inhibitor , ameliorated the histone acetylation defects , significantly improved motor performance , and extended the average life span of Atro-118Q mice .

腹腔注射组蛋白脱乙酰基酶的抑制剂&丁酸钠，能够提高Atro-118Q小鼠脑组织中组蛋白的乙酰化水平，同时缓解了Atro-118Q小鼠的运动缺陷，延长了小鼠的寿命。

Objective : To investigate the synergistic effects of a histone deacetylase inhibitor , trichostatin A ( TSA ), combined with cisplatin ( DDP ) on cisplatin-resistant ovarian epithelial cancer cell line C13 .

目的：本研究探讨组蛋白去乙酰化酶抑制剂TrichostatinA（TSA）联合化疗药物顺铂（DDP）处理人卵巢癌顺铂耐药株C13的协同效应。

Histone deacetylase inhibitor ( HDACi ) has been shown to demethylate mammalian genome , which further strengthens the concept that DNA methylation and histone modifications interact in regulation of gene expression .

已有报道证实组蛋白去乙酰化酶抑制剂（HDACi）可以引起哺乳动物基因组的去甲基化，这支持了DNA甲基化和组蛋白修饰可以相互作用调节基因的表达的观点。

As the first found natural histone deacetylase inhibitor , recent studies have found that Trichostatin A ( TSA ) had inhibitory effect on many tumor cells by inducing tumor cell apoptosis and cell differentiation , blocking cell cycles and so on .

曲古抑菌素A是一种重要的组蛋白去乙酰化酶抑制剂，近年来研究发现，其对多种肿瘤细胞具有抑制作用，作用机理包括诱导肿瘤细胞凋亡、阻滞细胞周期和促进细胞分化等。

Objective To explore the blockade effect of phenylbutyrate ( PB ), a histone deacetylase inhibitor , on the in vitro biological function of AML1 / ETO to reverse its transcription repression and induce Kasumi-1 cells to differentiate and apoptosis .

目的探讨组蛋白脱乙酰化酶抑制剂苯丁酸钠（PB）体外阻断AML1ETO的生物学功能，消除AML1ETO的转录抑制，诱导Kasumi1细胞生长抑制、分化和凋亡作用。

Objective : To improve the synthetic procedure of the histone deacetylase ( HDAC ) inhibitor SAHA .

目的：改进组蛋白去乙酰化酶抑制剂SAHA的合成工艺。

The paper proposed a possible binding mode of MS-275 , a benzamide histone deacetylase ( HDAC ) inhibitor , to HDAC by intensive docking study .

通过计算机模拟的对接过程研究，发现了MS-275&一种苯甲酰胺类的组蛋白去乙酰酶（HDAC）抑制剂与酶的可能的全新结合方式。

Objective : To investigate the influence of trichostatin A ( TSA ), a histone deacetylase ( HDAC ) inhibitor , on the growth of human bladder cancer cells and on the expression of related genes , and to explore the mechanism involved .

目的：观察组蛋白去乙酰化酶（HDAC）抑制剂曲古霉素A（TSA）对体外培养膀胱癌细胞生长情况及相关基因表达的影响，并探讨其可能的作用机制。

This study was to evaluate enhancive effect of trichostatin A ( TSA ), a histone deacetylase ( HDAC ) inhibitor , on the transfection efficiency of adenovirus in ovarian carcinoma cell line A2780 , and explore its possible application to adenovirus-based gene therapy .

本研究通过观察组氨酸去乙酰化酶（HistoneDeacetylase，HDAC）抑制剂TrichostatinA（TSA）对卵巢癌细胞株A2780CAR表达水平的影响，探讨HDAC抑制剂在腺病毒载体基因治疗中应用的可能性。